：Bitter melon extract powder

The Photo of Raw Material	Powder Extract Sample	Molecular Structure of Active Ingredient

Phytochemicals and Constituents of Momordica charantia:
Glycosides: momordin, charantin
Alkaloids: momordicin
Others: polypeptide-P
Oils (seed only): stearic, linoleic, oleic acids
Glycoproteins: alpha-momorcharin, beta-momorcharin, lectins
Others: vicine (pyrimidine nucleoside), protein MAP30
At least three different groups of constituents in bitter melon have been reported to have blood-sugar lowering actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these is most effective, or if all three work together. Some clinical trials have confirmed the benefit of bitter melon for people with diabetes.
In traditional herbal medicine, bitter melon,like other bitter-tasting herbs,is thought to stimulate digestive function and improve appetite. This has yet to be tested in human studies.
Charantin and Blood sugar management:
Momordica charantia (bitter melon) is a proven hypoglycemic agent. One of the active principles responsible for this action is charantin, which is composed of a mixture of beta-sitosterol-beta-D-glucoside and 5,25 stigmadien-3-beta-ol glycoside. It is therefore important that the extract be standardized for both total bitter principles and charantin.
Momordica charantia is a potential herbal alternative for blood sugar management, particularly in non-insulin dependent diabetes. An extract standardized for all the active principles would have proven efficacy in this regard.
The standardized extract of Momordica charantia, contains bitter principles and charantin.
Purification and characterization of Charantin:
A peptide designated charantin, with a molecular mass of 9.7 kDa, was isolated from bitter gourd seeds. The procedure comprised affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono S and gel filtration on Superdex 75. The N-terminal sequence of charantin exhibited marked similarity to that of the 7.8-kDa napin-like peptide previously isolated from bitter gourd seeds. Charantin inhibited cell-free translation in a rabbit reticulocyte lysate system with an IC50 of 400 nm, a potency lower than that of the previously reported small ribosome-inactivating protein gamma-momorcharin (IC50 = 55 nm) which also exhibited an abundance of arginine and glutamate/glutamine residues. Charantin reacted positively in the N-glycosidase assay, yielding a band similar to that formed by the small ribosome-inactivating proteins gamma-momorcharin and luffin S.

Bitter Melon Extract Momordica charantia Charantin Insulin-like peptides

1. Where grown:
   Bitter melon grows in tropical areas, including parts of East Africa, Asia, the Caribbean, and South America, where it is used as a food as well as a medicine.
   
2. Parts used:
   Fruit.
3. Supportive:
4. Diabetes
5. HIV
6. Psoriasis
7. Historical Usage:Being a relatively common food item, bitter melon was traditionally used for a dazzling array of conditions by people in tropical regions. Numerous infections, cancer, and diabetes are among the most common conditions it was purported to improve. The leaves and fruit have both been used occasionally to make teas and beer or to season soups in the Western world. The berries also produce wax, which can be made into candles.
8. Active Ingredinets: At least there are three different groups of constituents in bitter melon have been reported to have hypoglycemic (blood sugar lowering) or other actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these